This is a very fresh report, meaning we've done no analysis, but the experience has been confirmed by one other customer. We're now looking to see if others are experiencing this:

----- from a user ----------

We recently deployed a corporate install of McAfee on all of our desktops last week and guess what happened?

Our group is one of the first in my company that is running Win 7 Pro. Everything has been golden for the past few months until last week. Once the autodeploy occurred on Wednesday night last week, Thursday was hell on earth for our Win 7 users. 3ds Max 2010, 2011 and Autocad 2010 and 2011 started to lockup randomly throughout the day, pegging 1 CPU at 100% for 30 seconds to 20 minutes. This was almost as if we were saving a very large scene or running a particularly complete Maxscript. Sometimes, you could actually get 3ds Max to respond, but it was as if the machine was rendering in the background (render farm).

In any case, we could not quite nail it down at first. What ended up working was to manually disable McAfee through a sequence of very clever hacks. This was necessary due to the way McAfee is installed and controlled via group policies and the domain. Anyway, once this was done, I installed Microsoft Security Essentials, rebooted the machines and all is well. We were running Symantec Corporate AV for Win 7 with no problems.

This only seems to affect our Win 7 users and only Autodesk, or at least Autocad and 3ds Max. I cannot quite nail down exactly what is happening, but it makes your machine unusable.
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So, my question is anyone else able to find a relationship between performance issues and the latest McAfee? How big of a problem do we have? It's going to take time for us to understand this, so please don't expect instant resolution.